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sto 609  (Tocris)


Bioz Verified Symbol Tocris is a verified supplier
Bioz Manufacturer Symbol Tocris manufactures this product  
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    Structured Review

    Tocris sto 609
    Sto 609, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 97 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/sto+609/STO-609+acetate/pmc12757589-40-0-2
    Average 93 stars, based on 97 article reviews
    sto 609 - by Bioz Stars, 2026-10
    93/100 stars

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    Related Articles

    Isolation:

    Article Title: CAMKK2 is upregulated in primary human osteoarthritis and its inhibition protects against chondrocyte apoptosis.
    Article Snippet: Objective: To investigate the role of calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) in human osteoarthritis.. Materials and methods: Paired osteochondral plugs and articular chondrocytes were isolated from the relatively healthier (intact) and damaged portions of human femoral heads collected from patients undergoing total hip arthroplasty for primary osteoarthritis (OA).. Cartilage from femoral plugs were either flash frozen for gene expression analysis or histology and immunohistochemistry.

    Expressing:

    Article Title: CAMKK2 is upregulated in primary human osteoarthritis and its inhibition protects against chondrocyte apoptosis.
    Article Snippet: Objective: To investigate the role of calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) in human osteoarthritis.. Materials and methods: Paired osteochondral plugs and articular chondrocytes were isolated from the relatively healthier (intact) and damaged portions of human femoral heads collected from patients undergoing total hip arthroplasty for primary osteoarthritis (OA).. Cartilage from femoral plugs were either flash frozen for gene expression analysis or histology and immunohistochemistry.

    Significance Assay:

    Article Title: CAMKK2 is upregulated in primary human osteoarthritis and its inhibition protects against chondrocyte apoptosis.
    Article Snippet: Objective: To investigate the role of calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) in human osteoarthritis.. Materials and methods: Paired osteochondral plugs and articular chondrocytes were isolated from the relatively healthier (intact) and damaged portions of human femoral heads collected from patients undergoing total hip arthroplasty for primary osteoarthritis (OA).. Cartilage from femoral plugs were either flash frozen for gene expression analysis or histology and immunohistochemistry.

    Comparison:

    Article Title: CAMKK2 is upregulated in primary human osteoarthritis and its inhibition protects against chondrocyte apoptosis.
    Article Snippet: Objective: To investigate the role of calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) in human osteoarthritis.. Materials and methods: Paired osteochondral plugs and articular chondrocytes were isolated from the relatively healthier (intact) and damaged portions of human femoral heads collected from patients undergoing total hip arthroplasty for primary osteoarthritis (OA).. Cartilage from femoral plugs were either flash frozen for gene expression analysis or histology and immunohistochemistry.

    Recombinant:

    Article Title: Leptin increases GABAergic synaptogenesis through the Rho guanine exchange factor β-PIX in developing hippocampal neurons
    Article Snippet: .. Full-length rat recombinant leptin (50nM, Peprotech #400-21) and STO-609 (20μM, Tocris #1551) were used as described in the text and figure legends. ..

    Incubation:

    Article Title: Adipose triglyceride lipase is regulated by CAMKK2-AMPK signaling and drives advanced prostate cancer
    Article Snippet: .. After 48 h, cells were treated with STO-609 (Cat # 1551, Tocris, Bristol, UK) or SGC-CAMKK2-1 (Cat#SML2834, Sigma, St. Louis, MO, USA) and incubated for 3 or 7 days. ..

    Article Title: Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity
    Article Snippet: .. After 48 hours, cells were treated with STO-609 (cat #1551, Tocris) or SGC-CAMKK2–1 (cat. #SML2834, Sigma) and incubated for 3 or 7 days. ..

    other:

    Article Title: A Novel Pro-Inflammatory Mechanosensing Pathway Orchestrated by the Disintegrin Metalloproteinase ADAM15 in Synovial Fibroblasts
    Article Snippet: SF (3.5 × 10 5 cells/well), grown in BioFlex/type I collagen plates for 48 h, were pre-incubated for 30 min with DMEM-containing inhibitors and subjected to mechanical strain for various time points, using SP600125 (50 μM) (S5567-10MG), dasatinib (1 μM) (SML2589-50MG) and GSK2193874 (2.5 μM) (SML0942) from Sigma-Aldrich; Taufkirchen, Germany, KN-93 (50 μM) (#1278)and STO-609 (2.5 μM) (#1551) from Tocris Bioscience; Wiesbaden-Nordenstadt; Germany, TFP (trifluoperazine) (50 μM, Santa Cruz Biotechnology; Heidelberg, Germany, sc-201498), selisistat (50 and 100 μM) (S1541) and carbenoxolone (100 μM) (S4368) from Selleckchem; Munich, Germany.

    Article Title: Ca V 1.2-dependent excitation-transcription coupling modulates nociception
    Article Snippet: Stock solutions were prepared as indicated in parentheses of the following compounds: Autocamtide-2 Related Inhibitory Peptide (AIP, Calbiochem, #189480, 500 μM in dH2O), (S)-(-)-Bay K 8644 (BayK, Alomone Labs, #B-351, 50 mM in DMSO), Capsaicin (Cap, Sigma-Aldrich, #M2028, 10 mM in DMSO), Cyclosporin A (CsA, Tocris, #1101, 50 mM in DMSO), H-89 Dihydrochloride (H89, Tocris, #2910, 25 mM in DMSO), KN93 (Tocris, #1278; 20 mM in DMSO), Nifedipine (Nife, Tocris, #1075, 10 mM in DMSO), Nimodipine (Nimo, Tocris, #0600, 10 mM in DMSO), STO-609 (Tocris, #1551, 10 mM in DMSO), U0126 (Calbiochem, #662005, 50 mM in DMSO), Verapamil (VP, Alomone Labs, #V-100, 100 mM stock in dH2O), Veratridine (VT, Alomone Labs; #V-110; 50 mM stock in DMSO), ω-agatoxin IVA (Alomone Labs, #STA-500, 200 μM stock in 0.1% BSA), ω-conotoxin GVIA (Alomone Labs, # C-300, 1 mM stock in 0.1% BSA), ω-conotoxin MVIIC (Alomone Labs, #C-150, 300 μM stock in 0.1% BSA).



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    camkkβ inhibitor sto 609  (Selleck Chemicals)
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    Oxidative stress activated AMPK in macrophages. (A) The H 2 O 2 levels in renal tissues at day 0, 3, 7, and 28 post-IRI were detected (n = 4). (B) Representative flow cytometry histogram and (C) quantification of phospho-AMPK levels in renal macrophages (n = 5). (D) Immunoblots and (E) quantification of phospho-AMPK levels in WT BMDMs treated with PBS or 50 μM H 2 O 2 for 30 min. (F) Representative flow cytometry histogram and (G) quantification of phospho-AMPK levels in BMDMs exposed to TGF-β, IL-6, H 2 O 2 , and hypoxia (n = 5). (H) Intracellular calcium levels were detected by Fluo-4 stain using flow cytometry (n = 4). (I) Representative flow cytometry histogram and (J) quantification of phospho-AMPK levels in BMDMs treated with 50 μM H 2 O 2 or 50 μM H 2 O 2 + 10 <t>μM</t> <t>STO-609</t> (n = 5). The results represent mean ± SEM. ∗p < 0.05, ∗∗∗p < 0.001, NS no significance.
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    sto 609  (Tocris)
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    Tocris sto 609
    Oxidative stress activated AMPK in macrophages. (A) The H 2 O 2 levels in renal tissues at day 0, 3, 7, and 28 post-IRI were detected (n = 4). (B) Representative flow cytometry histogram and (C) quantification of phospho-AMPK levels in renal macrophages (n = 5). (D) Immunoblots and (E) quantification of phospho-AMPK levels in WT BMDMs treated with PBS or 50 μM H 2 O 2 for 30 min. (F) Representative flow cytometry histogram and (G) quantification of phospho-AMPK levels in BMDMs exposed to TGF-β, IL-6, H 2 O 2 , and hypoxia (n = 5). (H) Intracellular calcium levels were detected by Fluo-4 stain using flow cytometry (n = 4). (I) Representative flow cytometry histogram and (J) quantification of phospho-AMPK levels in BMDMs treated with 50 μM H 2 O 2 or 50 μM H 2 O 2 + 10 <t>μM</t> <t>STO-609</t> (n = 5). The results represent mean ± SEM. ∗p < 0.05, ∗∗∗p < 0.001, NS no significance.
    Sto 609, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/sto+609/STO-609+acetate/pmc12757589-40-0-2
    Average 93 stars, based on 1 article reviews
    sto 609 - by Bioz Stars, 2026-10
    93/100 stars
    		  Buy from Supplier

    Image Search Results


    Oxidative stress activated AMPK in macrophages. (A) The H 2 O 2 levels in renal tissues at day 0, 3, 7, and 28 post-IRI were detected (n = 4). (B) Representative flow cytometry histogram and (C) quantification of phospho-AMPK levels in renal macrophages (n = 5). (D) Immunoblots and (E) quantification of phospho-AMPK levels in WT BMDMs treated with PBS or 50 μM H 2 O 2 for 30 min. (F) Representative flow cytometry histogram and (G) quantification of phospho-AMPK levels in BMDMs exposed to TGF-β, IL-6, H 2 O 2 , and hypoxia (n = 5). (H) Intracellular calcium levels were detected by Fluo-4 stain using flow cytometry (n = 4). (I) Representative flow cytometry histogram and (J) quantification of phospho-AMPK levels in BMDMs treated with 50 μM H 2 O 2 or 50 μM H 2 O 2 + 10 μM STO-609 (n = 5). The results represent mean ± SEM. ∗p < 0.05, ∗∗∗p < 0.001, NS no significance.

    Journal: Redox Biology

    Article Title: Macrophage AMPK activated by oxidative stress drives profibrotic crosstalk with tubular cells to accelerate renal fibrosis after ischemic and reperfusion injury

    doi: 10.1016/j.redox.2025.104002

    Figure Lengend Snippet: Oxidative stress activated AMPK in macrophages. (A) The H 2 O 2 levels in renal tissues at day 0, 3, 7, and 28 post-IRI were detected (n = 4). (B) Representative flow cytometry histogram and (C) quantification of phospho-AMPK levels in renal macrophages (n = 5). (D) Immunoblots and (E) quantification of phospho-AMPK levels in WT BMDMs treated with PBS or 50 μM H 2 O 2 for 30 min. (F) Representative flow cytometry histogram and (G) quantification of phospho-AMPK levels in BMDMs exposed to TGF-β, IL-6, H 2 O 2 , and hypoxia (n = 5). (H) Intracellular calcium levels were detected by Fluo-4 stain using flow cytometry (n = 4). (I) Representative flow cytometry histogram and (J) quantification of phospho-AMPK levels in BMDMs treated with 50 μM H 2 O 2 or 50 μM H 2 O 2 + 10 μM STO-609 (n = 5). The results represent mean ± SEM. ∗p < 0.05, ∗∗∗p < 0.001, NS no significance.

    Article Snippet: For immunoblot analysis of phospho-AMPKα, BMDMs were treated with 50 μM H 2 O 2 for 30 min. To investigate calcium-dependent signaling, BMDMs were pretreated with the CaMKKβ inhibitor STO-609 (Selleck, S8274, 10 μM) or vehicle for 1 h prior to H 2 O 2 stimulation, and AMPK phosphorylation was quantified by flow cytometry.

    Techniques: Flow Cytometry, Western Blot, Staining